Domperidone for Drug-Induced Orthostatic Hypotension-A Review

Drug-induced orthostatic hypotension (Olf) is a commonside tifftct cfheterocyclic and AfAOI antidepressant medications. It usually does not respond to conservative treatment and drug treatments with mineralocorticoids or central dopaminergic antagonists such as metoclopramide have significant long-term side tifftcts that limit their use. Domperidone, a peripherally acting dopaminergic antagonist withjew sideeffects, has been used in a number qfsmall clinical trials to treat OH qf various etiologies. We reviewed 9 studies qf domperidone in the treatment qf OH. A lthough limited by small sample sizes and poor design, these studiesgenerally showed successful treatment ofOH by domperidone. Further controlled studies qf domperidone for antidepressantinduced OH in relevant patient samplesare warranted.